Parathyroid cyst formation induced by dihydrotachysterol and calcium acetate. An electron microscopic study.
نویسندگان
چکیده
Parathyroid cysts were produced in rats by excessive doses of dihydrotachysterol. (DHT) and calcium acetate. Although overdoses of each DHT, calcium or their combination are believed to suppress the activity of the parathyroid cell, the present electron microscopic observation showed signs of enhanced protein synthesis and secretion of the cells in all stages of cyst formation. It seems reasonable to assume that this cyst formation depends upon two main processes: retention of secretory material in the intercellular spaces and liquefaction necrosis of the paratkyroid cells which emerges in rather later stages of cyst formation.
منابع مشابه
Endocrine control of the intestinal calcium excretion.
Calcium excretion from rat intestine was measured by placing distilled water in an intestinal loop in situ and measuring the calcium content after various intervals. More calcium was excreted from the intestine of 18-month-old rats than that of 1-month-old rat. Acute hypocalcemia failed to change the intestinal calcium excretion significantly. Parathyroidectomy decreased intestinal calcium excr...
متن کاملCerebro-metacarpo-metatarsal Dystrophy (pseudo-pseudo Hypoparathyroidism) with Chromosomal Anomaly.
Albright, Burnett, Smith, and Parson (I942) investigated a female patient of 28 years who had suffered from idiopathic epilepsy since the age of I2. Because the bones of the skull were unusually dense, hypoparathyroidism was suspected. The diagnosis was made when it was found that her Chwostek sign was positive and that her serum calcium and phosphorus levels were 6-4 and 6o mg. per I00 ml. res...
متن کاملAzotemic renal osteodystrophy; clinical features and bone pathology.
During the hemodialysis treatment of 543 uremic patients for 10 years, significant complications concerning metabolic calcium disturbances, subperiosteal resorption, calcification of soft tissue or peripheral vessels, and fractures were noted. Significant elevation of alkaline phosphatase was induced for 5 years under hemodialysis using 5.0--6.0 mg/dl dialysate calcium, but not under 7.5 mg/dl ...
متن کاملThe Treatment of Experimental Hypoparathyroidism
In subtotal thyroidectomy in human subjects, a significant amount of the parathyroid tissue is frequently removed, so that some of these patients show the characteristic symptoms of hypoparathyroidism. Although preparations of parathyroid hormone are available for the treatment of this condition, administration of dihydrotachysterol -(Hytakerol) has become largely the method of choice, and clin...
متن کاملParathyroid hormone- and deoxycorticosterone acetate-induced hypertension in the rat.
1. Hypertension induced by treatment with deoxycorticosterone acetate and sodium chloride was studied in male Sprague-Dawley rats and related to parathyroid hormone secretion. 2. Lack of parathyroid hormone (due to parathyroidectomy) or decreased parathormone secretion (due to a high-calcium diet) partially inhibited the development of arterial hypertension. 3. In contrast, in thyroparathyroide...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Endocrinologia japonica
دوره 17 5 شماره
صفحات -
تاریخ انتشار 1970